Antidepressants: sexual dysfunction: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Antidepressants: sexual dysfunction

Sample item

A man on sertraline develops delayed ejaculation and reduced libido. Which switching option is least likely to cause sexual dysfunction?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Bupropion or mirtazapine

SSRIs and SNRIs commonly cause anorgasmia and sexual dysfunction through serotonergic effects. Bupropion, mirtazapine and agomelatine carry less risk, and PDE-5 inhibitors can be added.

Option by option

  • A. Venlafaxine

    Venlafaxine also causes sexual side effects.

  • B. Bupropion or mirtazapine (correct)

    Correct. These have the lowest incidence of sexual side effects.

  • C. Clomipramine

    Clomipramine is highly serotonergic and impairs sexual function.

  • D. Paroxetine

    Paroxetine causes a high rate of sexual dysfunction.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is B, Bupropion or mirtazapine. SSRIs and SNRIs commonly cause anorgasmia and sexual dysfunction through serotonergic effects.

Why is "Venlafaxine" not the answer?

Venlafaxine also causes sexual side effects.

Why is "Clomipramine" not the answer?

Clomipramine is highly serotonergic and impairs sexual function.

Why is "Paroxetine" not the answer?

Paroxetine causes a high rate of sexual dysfunction.

What concept does this question test?

It tests Antidepressants: sexual dysfunction in Psychiatry. Bupropion, mirtazapine and agomelatine carry less risk, and PDE-5 inhibitors can be added.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antidepressants: sexual dysfunction?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.