Antidepressants: bleeding risk: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Antidepressants: bleeding risk

Sample item

SSRIs increase the risk of gastrointestinal bleeding especially when combined with:

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. NSAIDs

SSRIs deplete platelet serotonin, impairing aggregation, and the risk rises sharply with NSAIDs or anticoagulants. A proton pump inhibitor may be co-prescribed in high-risk patients.

Option by option

  • A. NSAIDs (correct)

    Correct. NSAIDs combined with SSRIs raise GI bleeding risk.

  • B. Paracetamol

    Paracetamol does not impair platelets.

  • C. Proton pump inhibitors

    PPIs lower GI bleeding risk.

  • D. Thyroxine

    Thyroxine does not add to this risk.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is A, NSAIDs. SSRIs deplete platelet serotonin, impairing aggregation, and the risk rises sharply with NSAIDs or anticoagulants.

Why is "Paracetamol" not the answer?

Paracetamol does not impair platelets.

Why is "Proton pump inhibitors" not the answer?

PPIs lower GI bleeding risk.

Why is "Thyroxine" not the answer?

Thyroxine does not add to this risk.

What concept does this question test?

It tests Antidepressants: bleeding risk in Psychiatry. A proton pump inhibitor may be co-prescribed in high-risk patients.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antidepressants: bleeding risk?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.