Antidepressants: agomelatine: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Antidepressants: agomelatine

Sample item

Which antidepressant is an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C, and requires monitoring of liver function?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Agomelatine

Agomelatine resynchronises circadian rhythms and improves sleep, with low sexual dysfunction and no weight gain. Because of hepatotoxicity, liver function tests are done before and during treatment.

Option by option

  • A. Venlafaxine

    Venlafaxine is an SNRI.

  • B. Moclobemide

    Moclobemide is a reversible MAO-A inhibitor.

  • C. Agomelatine (correct)

    Correct. Agomelatine is a melatonergic agonist and 5-HT2C antagonist.

  • D. Reboxetine

    Reboxetine is a selective noradrenaline reuptake inhibitor.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is C, Agomelatine. Agomelatine resynchronises circadian rhythms and improves sleep, with low sexual dysfunction and no weight gain.

Why is "Venlafaxine" not the answer?

Venlafaxine is an SNRI.

Why is "Moclobemide" not the answer?

Moclobemide is a reversible MAO-A inhibitor.

Why is "Reboxetine" not the answer?

Reboxetine is a selective noradrenaline reuptake inhibitor.

What concept does this question test?

It tests Antidepressants: agomelatine in Psychiatry. Because of hepatotoxicity, liver function tests are done before and during treatment.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antidepressants: agomelatine?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.