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ENT · Head and neck tumours: Pemberton sign
Sample itemA 60-year-old woman with a long-standing multinodular goitre develops facial plethora, distended neck veins and dizziness when she raises both arms above her head. What is the mechanism?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Venous obstruction at the thoracic inlet by a retrosternal goitre
Raising the arms pulls the thoracic inlet upwards, and a retrosternal or large goitre wedged there obstructs venous return, causing facial congestion and dizziness. This is Pemberton sign and suggests thoracic inlet obstruction.
Option by option
A. Tracheal compression by a hot nodule
Tracheal compression causes stridor and dyspnoea, not facial congestion on raising the arms.
B. Venous obstruction at the thoracic inlet by a retrosternal goitre (correct)
Correct. A goitre wedged in the thoracic inlet obstructs venous return when the arms are raised.
C. Recurrent laryngeal nerve invasion
Recurrent laryngeal nerve invasion causes hoarseness and suggests malignancy.
D. Carotid artery compression by the goitre
Carotid compression would not produce venous congestion of the face.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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