Complications of pregnancy: gestational trophoblastic disease: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Complications of pregnancy: gestational trophoblastic disease

Sample item

Eight weeks after evacuation of a complete mole, a woman's hCG has plateaued over three weeks (four weekly measurements). She is not pregnant. Which diagnosis fits?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Gestational trophoblastic neoplasia

A plateau or rise of hCG after evacuation of a mole defines persistent disease, termed gestational trophoblastic neoplasia (invasive mole or choriocarcinoma). Staging then guides treatment with methotrexate or combination chemotherapy. Normal regression shows a steady fall.

Option by option

  • A. Gestational trophoblastic neoplasia (correct)

    Correct. A plateaued hCG after a mole is gestational trophoblastic neoplasia.

  • B. Retained decidua without trophoblast

    Decidua does not secrete hCG.

  • C. Normal regression of hCG

    Normal regression produces a progressive fall, not a plateau.

  • D. Physiological pituitary hCG secretion

    Pituitary hCG is minimal and occurs in postmenopausal women, not here.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is A, Gestational trophoblastic neoplasia. A plateau or rise of hCG after evacuation of a mole defines persistent disease, termed gestational trophoblastic neoplasia (invasive mole or choriocarcinoma).

Why is "Retained decidua without trophoblast" not the answer?

Decidua does not secrete hCG.

Why is "Normal regression of hCG" not the answer?

Normal regression produces a progressive fall, not a plateau.

Why is "Physiological pituitary hCG secretion" not the answer?

Pituitary hCG is minimal and occurs in postmenopausal women, not here.

What concept does this question test?

It tests Complications of pregnancy: gestational trophoblastic disease in OBG. Staging then guides treatment with methotrexate or combination chemotherapy. Normal regression shows a steady fall.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Complications of pregnancy: gestational trophoblastic disease?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.