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OBG · Infertility and contraception: fertility preservation
Sample itemA 28-year-old unmarried woman with breast cancer is to start chemotherapy in 10 days and wants her own biological children later. Which option is best?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Ovarian stimulation and oocyte vitrification
Oocyte cryopreservation after rapid ovarian stimulation, started at any cycle phase, is the established option for a woman without a partner. Oral pills do not protect the ovaries. Ovarian drilling is used for anovulation in PCOS. Clomiphene alone does not preserve fertility.
Option by option
A. Clomiphene citrate
Clomiphene would not preserve eggs and delays treatment.
B. Ovarian stimulation and oocyte vitrification (correct)
Correct. Stored oocytes retain fertility potential against gonadotoxic drugs.
C. Oral contraceptive pills during chemotherapy
Oral pills do not protect the ovarian reserve.
D. Laparoscopic ovarian drilling
Drilling is a treatment for ovulatory infertility in PCOS.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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