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Psychiatry · Mood disorders: kindling in bipolar disorder
Sample itemIn bipolar disorder, successive episodes tend to come closer together and later ones occur without any stressor. Which hypothesis explains this?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Kindling
The kindling hypothesis proposes that each episode sensitises neural circuits so later episodes need less provocation, as repeated subthreshold stimulation eventually produces seizures. It is used to argue for early and sustained mood-stabiliser treatment.
Option by option
A. Learned helplessness
Learned helplessness explains depressive passivity after uncontrollable stress.
B. Cognitive triad
The cognitive triad of negative views of self, world and future is Beck's model of depression.
C. Monoamine depletion
Monoamine depletion is a biochemical hypothesis of depression, not of increasing frequency.
D. Kindling (correct)
Correct. Episodes sensitise the brain, so later ones appear spontaneously and more often.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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