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ENT · Pharynx and tonsils: secondary syphilis of the mouth
Sample itemA sexually active man has a sore throat, painless greyish-white erosions on the tongue and cheek, a non-itchy palmar rash and generalised lymphadenopathy. Which diagnosis fits best?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Secondary syphilis
Mucous patches are painless greyish erosions of secondary syphilis, seen with a palmar and plantar rash and lymphadenopathy. Serology confirms it and benzathine penicillin treats it. Lichen planus has reticular white streaks without a rash like this.
Option by option
A. Oral lichen planus
Lichen planus has lacy white striae and no palmar rash.
B. Herpes simplex stomatitis
Herpes gives painful clustered vesicles, not painless erosions.
C. Secondary syphilis (correct)
Correct. Painless mucous patches with palmar rash and lymphadenopathy indicate secondary syphilis.
D. Oral candidiasis
Candidiasis gives wipeable plaques and is not associated with a palmar rash.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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