Normal pregnancy and antenatal care: teratogens: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Normal pregnancy and antenatal care: teratogens

Sample item

A child born to a woman who took warfarin in the first trimester has a flattened nasal bridge and stippled epiphyses on radiograph. Which condition is this?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Warfarin embryopathy

Warfarin taken in weeks 6 to 12 causes nasal hypoplasia and chondrodysplasia punctata, with later risk of optic atrophy and intracranial bleeding. Women with mechanical valves need a carefully planned anticoagulation regimen before conception.

Option by option

  • A. Warfarin embryopathy (correct)

    Correct. Nasal hypoplasia with stippled epiphyses is typical.

  • B. Thalidomide embryopathy

    Thalidomide causes phocomelia, not stippled epiphyses.

  • C. Fetal alcohol syndrome

    Fetal alcohol syndrome features a smooth philtrum, thin upper lip and microcephaly.

  • D. Fetal hydantoin syndrome

    Hydantoin syndrome features hypoplastic nails and digits with craniofacial change.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this OBG question

What is the answer to this OBG question?

The best answer is A, Warfarin embryopathy. Warfarin taken in weeks 6 to 12 causes nasal hypoplasia and chondrodysplasia punctata, with later risk of optic atrophy and intracranial bleeding.

Why is "Thalidomide embryopathy" not the answer?

Thalidomide causes phocomelia, not stippled epiphyses.

Why is "Fetal alcohol syndrome" not the answer?

Fetal alcohol syndrome features a smooth philtrum, thin upper lip and microcephaly.

Why is "Fetal hydantoin syndrome" not the answer?

Hydantoin syndrome features hypoplastic nails and digits with craniofacial change.

What concept does this question test?

It tests Normal pregnancy and antenatal care: teratogens in OBG. Women with mechanical valves need a carefully planned anticoagulation regimen before conception.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Normal pregnancy and antenatal care: teratogens?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.