Systemic paediatrics: post-streptococcal glomerulonephritis: practice question

A Pediatrics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pediatrics · Systemic paediatrics: post-streptococcal glomerulonephritis

Sample item

A boy with post-streptococcal glomerulonephritis still has a low C3 level and haematuria 4 months later. What should be suspected?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Membranoproliferative glomerulonephritis

C3 normally returns to normal within 6 to 8 weeks after post-streptococcal glomerulonephritis. Persistent hypocomplementaemia beyond 12 weeks suggests another disease such as membranoproliferative glomerulonephritis. A biopsy is then needed.

Option by option

  • A. Normal recovery

    Normal recovery does not leave C3 low after 4 months.

  • B. Membranoproliferative glomerulonephritis (correct)

    Correct. Persisting low C3 suggests a chronic complement-mediated disease.

  • C. Minimal change disease

    Minimal change disease has no haematuria and normal C3.

  • D. IgA nephropathy

    IgA nephropathy has normal complement levels.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pediatrics question

What is the answer to this Pediatrics question?

The best answer is B, Membranoproliferative glomerulonephritis. C3 normally returns to normal within 6 to 8 weeks after post-streptococcal glomerulonephritis.

Why is "Normal recovery" not the answer?

Normal recovery does not leave C3 low after 4 months.

Why is "Minimal change disease" not the answer?

Minimal change disease has no haematuria and normal C3.

Why is "IgA nephropathy" not the answer?

IgA nephropathy has normal complement levels.

What concept does this question test?

It tests Systemic paediatrics: post-streptococcal glomerulonephritis in Pediatrics. Persistent hypocomplementaemia beyond 12 weeks suggests another disease such as membranoproliferative glomerulonephritis. A biopsy is then needed.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Systemic paediatrics: post-streptococcal glomerulonephritis?

Memorise milestones and the vaccine schedule as tables and revise them often. Then use the flashcards and the other Pediatrics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.