Psychopharmacology: nefazodone hepatotoxicity: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Psychopharmacology: nefazodone hepatotoxicity

Sample item

Which antidepressant has been withdrawn or restricted in many countries because of rare but fatal hepatic failure?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Nefazodone

Nefazodone carries a risk of severe idiosyncratic hepatotoxicity, leading to its withdrawal in many markets. Liver function monitoring is needed in any patient still prescribed it.

Option by option

  • A. Venlafaxine

    Venlafaxine is associated with dose-related hypertension and discontinuation symptoms.

  • B. Mirtazapine

    Mirtazapine is associated with weight gain and sedation, not liver failure.

  • C. Nefazodone (correct)

    Correct. It is associated with rare fatal liver failure.

  • D. Sertraline

    Sertraline is generally safe for the liver in standard use.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is C, Nefazodone. Nefazodone carries a risk of severe idiosyncratic hepatotoxicity, leading to its withdrawal in many markets.

Why is "Venlafaxine" not the answer?

Venlafaxine is associated with dose-related hypertension and discontinuation symptoms.

Why is "Mirtazapine" not the answer?

Mirtazapine is associated with weight gain and sedation, not liver failure.

Why is "Sertraline" not the answer?

Sertraline is generally safe for the liver in standard use.

What concept does this question test?

It tests Psychopharmacology: nefazodone hepatotoxicity in Psychiatry. Liver function monitoring is needed in any patient still prescribed it.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Psychopharmacology: nefazodone hepatotoxicity?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.