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Psychiatry · Psychopharmacology: benzodiazepines and respiratory disease
Sample itemA 70-year-old woman with severe COPD and carbon dioxide retention has generalised anxiety disorder. Which drug is the most appropriate for her anxiety?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Buspirone
Benzodiazepines depress respiratory drive and can precipitate hypercapnic failure in severe COPD, while buspirone does not cause respiratory depression. An SSRI is also an option for long-term treatment.
Option by option
A. Alprazolam
Alprazolam is a benzodiazepine that can worsen CO2 retention.
B. Buspirone (correct)
Correct. Buspirone is non-sedating and has no respiratory depressant effect.
C. Clonazepam
Clonazepam is a benzodiazepine with the same respiratory risk.
D. Diazepam
Diazepam is long-acting and accumulates in older people, with respiratory depression.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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