Haematopathology: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Haematopathology

Sample item

Binucleate 'owl-eye' cells that stain for CD15 and CD30 are characteristic of which condition?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Classical Hodgkin lymphoma

Reed–Sternberg cells with large owl-eye nucleoli, positive for CD15 and CD30, define classical Hodgkin lymphoma. They sit in a background of reactive inflammatory cells.

Option by option

  • A. Multiple myeloma

    Myeloma shows clonal plasma cells with CD138.

  • B. Hairy cell leukaemia

    Hairy cell leukaemia shows cells with cytoplasmic projections and TRAP positivity.

  • C. Classical Hodgkin lymphoma (correct)

    Correct.

  • D. Burkitt lymphoma

    Burkitt lymphoma shows a 'starry sky' pattern with CD20-positive cells.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Classical Hodgkin lymphoma. Reed–Sternberg cells with large owl-eye nucleoli, positive for CD15 and CD30, define classical Hodgkin lymphoma.

Why is "Multiple myeloma" not the answer?

Myeloma shows clonal plasma cells with CD138.

Why is "Hairy cell leukaemia" not the answer?

Hairy cell leukaemia shows cells with cytoplasmic projections and TRAP positivity.

Why is "Burkitt lymphoma" not the answer?

Burkitt lymphoma shows a 'starry sky' pattern with CD20-positive cells.

What concept does this question test?

It tests Haematopathology in Pathology. They sit in a background of reactive inflammatory cells.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Haematopathology?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.