Ovarian physiology: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Ovarian physiology

Sample item

Within a developing ovarian follicle, which cells directly surround the oocyte, respond to FSH, express aromatase and secrete oestradiol and inhibin B?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Granulosa cells

Granulosa cells line the follicle and surround the oocyte. FSH induces aromatase in them to convert androgens from theca cells to oestrogen. Theca cells respond to LH and produce androgens.

Option by option

  • A. Theca interna cells

    Theca interna cells respond to LH and make androgens.

  • B. Ovarian stromal cells

    Stromal cells provide support and are not the oestradiol-producing layer.

  • C. Granulosa cells (correct)

    Correct. These FSH-responsive cells aromatise androgens to oestradiol.

  • D. Hilar Leydig-type cells

    Hilar cells are androgen-secreting cells near the ovarian hilum.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this OBG question

What is the answer to this OBG question?

The best answer is C, Granulosa cells. Granulosa cells line the follicle and surround the oocyte.

Why is "Theca interna cells" not the answer?

Theca interna cells respond to LH and make androgens.

Why is "Ovarian stromal cells" not the answer?

Stromal cells provide support and are not the oestradiol-producing layer.

Why is "Hilar Leydig-type cells" not the answer?

Hilar cells are androgen-secreting cells near the ovarian hilum.

What concept does this question test?

It tests Ovarian physiology in OBG. FSH induces aromatase in them to convert androgens from theca cells to oestrogen. Theca cells respond to LH and produce androgens.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Ovarian physiology?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.