Cardiology: Heyde syndrome: practice question

A General Medicine question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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General Medicine · Cardiology: Heyde syndrome

Sample item

An elderly patient with calcific aortic stenosis has recurrent gastrointestinal bleeding from colonic angiodysplasia and acquired von Willebrand syndrome. What is this called?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Heyde syndrome

Heyde syndrome links severe aortic stenosis with gastrointestinal angiodysplasia bleeding. High shear stress cleaves large von Willebrand multimers, giving acquired type 2A von Willebrand syndrome. Aortic valve replacement corrects the coagulopathy.

Option by option

  • A. Peutz-Jeghers syndrome

    Peutz-Jeghers has hamartomatous polyps and pigmented lips.

  • B. Osler-Weber-Rendu syndrome

    Osler-Weber-Rendu is hereditary telangiectasia without AS-related VWF loss.

  • C. Plummer-Vinson syndrome

    Plummer-Vinson is dysphagia with iron deficiency and oesophageal web.

  • D. Heyde syndrome (correct)

    Correct. This triad defines Heyde syndrome.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this General Medicine question

What is the answer to this General Medicine question?

The best answer is D, Heyde syndrome. Heyde syndrome links severe aortic stenosis with gastrointestinal angiodysplasia bleeding.

Why is "Peutz-Jeghers syndrome" not the answer?

Peutz-Jeghers has hamartomatous polyps and pigmented lips.

Why is "Osler-Weber-Rendu syndrome" not the answer?

Osler-Weber-Rendu is hereditary telangiectasia without AS-related VWF loss.

Why is "Plummer-Vinson syndrome" not the answer?

Plummer-Vinson is dysphagia with iron deficiency and oesophageal web.

What concept does this question test?

It tests Cardiology: Heyde syndrome in General Medicine. High shear stress cleaves large von Willebrand multimers, giving acquired type 2A von Willebrand syndrome. Aortic valve replacement corrects the coagulopathy.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Cardiology: Heyde syndrome?

For each disease know the classic presentation, the best test, and the first-line treatment. Then use the flashcards and the other General Medicine questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.