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General Medicine · Nephrology: anaemia of CKD
Sample itemA patient on dialysis has haemoglobin of 8 g/dL with normal transferrin saturation and ferritin. What is the treatment?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Erythropoiesis-stimulating agent after ensuring iron stores
Anaemia of CKD results mainly from deficient erythropoietin production. ESAs are used once iron deficiency is corrected, with a typical target haemoglobin of 10 to 11.5 g/dL to avoid thrombotic risk. Transfusions are avoided in transplant candidates to prevent sensitisation.
Option by option
A. Oral vitamin B12 only
B12 deficiency is not the cause here.
B. Corticosteroids
Steroids do not treat the cause.
C. Repeated transfusions
Transfusion is for emergencies, not routine.
D. Erythropoiesis-stimulating agent after ensuring iron stores (correct)
Correct. ESA with adequate iron is standard.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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