Endocrinology: LADA: practice question

A General Medicine question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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General Medicine · Endocrinology: LADA

Sample item

A 35-year-old lean adult is labelled type 2 diabetes but is anti-GAD antibody positive and needs insulin within 18 months of diagnosis. What is the diagnosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Latent autoimmune diabetes in adults

LADA is slowly progressive autoimmune diabetes in adults with positive islet antibodies such as anti-GAD, and early failure of oral agents. Insulin is needed within a few years. Sulfonylureas often hasten beta cell failure and are avoided.

Option by option

  • A. MODY

    MODY is antibody negative with a strong family history.

  • B. Latent autoimmune diabetes in adults (correct)

    Correct. Anti-GAD positivity with early insulin need defines LADA.

  • C. Gestational diabetes

    Gestational diabetes occurs in pregnancy.

  • D. Secondary diabetes from pancreatitis

    Pancreatitis would give a relevant history and imaging.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More General Medicine questions

Questions about this General Medicine question

What is the answer to this General Medicine question?

The best answer is B, Latent autoimmune diabetes in adults. LADA is slowly progressive autoimmune diabetes in adults with positive islet antibodies such as anti-GAD, and early failure of oral agents.

Why is "MODY" not the answer?

MODY is antibody negative with a strong family history.

Why is "Gestational diabetes" not the answer?

Gestational diabetes occurs in pregnancy.

Why is "Secondary diabetes from pancreatitis" not the answer?

Pancreatitis would give a relevant history and imaging.

What concept does this question test?

It tests Endocrinology: LADA in General Medicine. Insulin is needed within a few years. Sulfonylureas often hasten beta cell failure and are avoided.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Endocrinology: LADA?

For each disease know the classic presentation, the best test, and the first-line treatment. Then use the flashcards and the other General Medicine questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.