Neurology: Weber syndrome: practice question

A General Medicine question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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General Medicine · Neurology: Weber syndrome

Sample item

A patient has right oculomotor nerve palsy with a dilated pupil and left hemiparesis. Where is the lesion?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Right ventral midbrain

Weber syndrome is a ventral midbrain lesion affecting the oculomotor fascicles and the cerebral peduncle, giving ipsilateral third nerve palsy and contralateral hemiplegia. It is caused by a posterior cerebral artery branch occlusion. Claude syndrome adds ataxia from the red nucleus.

Option by option

  • A. Right medulla

    Medullary lesions affect lower cranial nerves.

  • B. Left internal capsule

    Capsular lesion does not cause a cranial nerve III palsy.

  • C. Right ventral midbrain (correct)

    Correct. Ipsilateral CN III with contralateral hemiplegia localises to the midbrain.

  • D. Left pons

    Pontine lesions cause CN VI or VII palsies.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this General Medicine question

What is the answer to this General Medicine question?

The best answer is C, Right ventral midbrain. Weber syndrome is a ventral midbrain lesion affecting the oculomotor fascicles and the cerebral peduncle, giving ipsilateral third nerve palsy and contralateral hemiplegia.

Why is "Right medulla" not the answer?

Medullary lesions affect lower cranial nerves.

Why is "Left internal capsule" not the answer?

Capsular lesion does not cause a cranial nerve III palsy.

Why is "Left pons" not the answer?

Pontine lesions cause CN VI or VII palsies.

What concept does this question test?

It tests Neurology: Weber syndrome in General Medicine. It is caused by a posterior cerebral artery branch occlusion. Claude syndrome adds ataxia from the red nucleus.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neurology: Weber syndrome?

For each disease know the classic presentation, the best test, and the first-line treatment. Then use the flashcards and the other General Medicine questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.