Rheumatology: Behcet disease: practice question

A General Medicine question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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General Medicine · Rheumatology: Behcet disease

Sample item

A young man from the Silk Route region has recurrent oral and genital ulcers, uveitis and a papule at needle-prick sites. Which HLA is associated?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. HLA-B51

Behcet disease is a variable vessel vasculitis with recurrent oral aphthae, genital ulcers, uveitis and a positive pathergy test, and is associated with HLA-B51. Vascular involvement includes venous thrombosis. Colchicine, steroids and immunosuppressants are used.

Option by option

  • A. HLA-B27

    HLA-B27 is associated with ankylosing spondylitis.

  • B. HLA-B51 (correct)

    Correct. HLA-B51 is associated with Behcet disease.

  • C. HLA-DQ2

    HLA-DQ2 is associated with coeliac disease.

  • D. HLA-DR3

    HLA-DR3 is associated with several autoimmune diseases, not Behcet.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More General Medicine questions

Questions about this General Medicine question

What is the answer to this General Medicine question?

The best answer is B, HLA-B51. Behcet disease is a variable vessel vasculitis with recurrent oral aphthae, genital ulcers, uveitis and a positive pathergy test, and is associated with HLA-B51.

Why is "HLA-B27" not the answer?

HLA-B27 is associated with ankylosing spondylitis.

Why is "HLA-DQ2" not the answer?

HLA-DQ2 is associated with coeliac disease.

Why is "HLA-DR3" not the answer?

HLA-DR3 is associated with several autoimmune diseases, not Behcet.

What concept does this question test?

It tests Rheumatology: Behcet disease in General Medicine. Vascular involvement includes venous thrombosis. Colchicine, steroids and immunosuppressants are used.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Rheumatology: Behcet disease?

For each disease know the classic presentation, the best test, and the first-line treatment. Then use the flashcards and the other General Medicine questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.