Infectious diseases: XDR typhoid: practice question

A General Medicine question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

General Medicine · Infectious diseases: XDR typhoid

Sample item

Salmonella Typhi isolated from a patient is resistant to chloramphenicol, ampicillin, cotrimoxazole, fluoroquinolones and ceftriaxone. What is the treatment?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Azithromycin, or a carbapenem for severe disease

Extensively drug-resistant typhoid lacks susceptibility to the three first-line agents, fluoroquinolones and third-generation cephalosporins, and is treated with azithromycin or carbapenems. Carbapenems are used for severe or complicated cases. Typhoid vaccination helps prevention.

Option by option

  • A. Ceftriaxone

    Ceftriaxone resistance is present.

  • B. Amoxicillin

    Ampicillin resistance is present.

  • C. Azithromycin, or a carbapenem for severe disease (correct)

    Correct. Azithromycin or a carbapenem remain active.

  • D. Ciprofloxacin

    Fluoroquinolone resistance is present.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More General Medicine questions

Questions about this General Medicine question

What is the answer to this General Medicine question?

The best answer is C, Azithromycin, or a carbapenem for severe disease. Extensively drug-resistant typhoid lacks susceptibility to the three first-line agents, fluoroquinolones and third-generation cephalosporins, and is treated with azithromycin or carbapenems.

Why is "Ceftriaxone" not the answer?

Ceftriaxone resistance is present.

Why is "Amoxicillin" not the answer?

Ampicillin resistance is present.

Why is "Ciprofloxacin" not the answer?

Fluoroquinolone resistance is present.

What concept does this question test?

It tests Infectious diseases: XDR typhoid in General Medicine. Carbapenems are used for severe or complicated cases. Typhoid vaccination helps prevention.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Infectious diseases: XDR typhoid?

For each disease know the classic presentation, the best test, and the first-line treatment. Then use the flashcards and the other General Medicine questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.