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General Surgery · Urology: prostate cancer bone metastases
Sample itemA man with prostate cancer has back pain and raised alkaline phosphatase. Which statement describes the likely metastatic pattern?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Osteoblastic vertebral lesions spreading via Batson venous plexus
Prostate cancer commonly metastasises to the axial skeleton via the valveless Batson vertebral venous plexus, producing sclerotic lesions with raised alkaline phosphatase. Spinal cord compression is an oncological emergency needing steroids and radiotherapy.
Option by option
A. Osteoblastic vertebral lesions spreading via Batson venous plexus (correct)
Correct. Osteoblastic lesions via Batson plexus are typical.
B. Brain metastases first
Brain metastases are uncommon.
C. Purely lytic skull lesions
Lytic lesions are more typical of renal and thyroid metastases.
D. Isolated pulmonary metastases only
Bone is the commonest site.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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