Vascular disorders: granulomatosis with polyangiitis: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Vascular disorders: granulomatosis with polyangiitis

Sample item

Which antibody pattern is characteristic of granulomatosis with polyangiitis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. c-ANCA (anti-proteinase 3)

Granulomatosis with polyangiitis, formerly Wegener, is typically c-ANCA positive with anti-proteinase 3 antibodies. It involves the upper and lower respiratory tracts and kidneys, and skin lesions include palpable purpura and ulcers. p-ANCA is more typical of microscopic polyangiitis and eosinophilic granulomatosis.

Option by option

  • A. p-ANCA (anti-MPO) only

    p-ANCA with MPO is more typical of microscopic polyangiitis.

  • B. c-ANCA (anti-proteinase 3) (correct)

    Correct. c-ANCA with PR3 is characteristic.

  • C. Anti-centromere

    Anti-centromere is seen in limited systemic sclerosis.

  • D. Anti-histone

    Anti-histone is seen in drug-induced lupus.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is B, c-ANCA (anti-proteinase 3). Granulomatosis with polyangiitis, formerly Wegener, is typically c-ANCA positive with anti-proteinase 3 antibodies.

Why is "p-ANCA (anti-MPO) only" not the answer?

p-ANCA with MPO is more typical of microscopic polyangiitis.

Why is "Anti-centromere" not the answer?

Anti-centromere is seen in limited systemic sclerosis.

Why is "Anti-histone" not the answer?

Anti-histone is seen in drug-induced lupus.

What concept does this question test?

It tests Vascular disorders: granulomatosis with polyangiitis in Dermatology. It involves the upper and lower respiratory tracts and kidneys, and skin lesions include palpable purpura and ulcers. p-ANCA is more typical of microscopic polyangiitis and eosinophilic granulomatosis.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Vascular disorders: granulomatosis with polyangiitis?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.