Blistering disorders: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Blistering disorders

Sample item

A patient has flaccid blisters that rupture easily and a positive Nikolsky sign. Which condition is most likely?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Pemphigus vulgaris

Pemphigus vulgaris is an intraepidermal blistering disease caused by antibodies against desmoglein 3, with suprabasal acantholysis. Bullous pemphigoid has tense blisters, subepidermal splits and a negative Nikolsky sign.

Option by option

  • A. Pemphigus vulgaris (correct)

    Correct.

  • B. Dermatitis herpetiformis

    Dermatitis herpetiformis is intensely itchy with grouped vesicles.

  • C. Bullous pemphigoid

    Bullous pemphigoid has tense, stable bullae.

  • D. Lichen planus

    Lichen planus is a papular eruption.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Dermatology questions

Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is A, Pemphigus vulgaris. Pemphigus vulgaris is an intraepidermal blistering disease caused by antibodies against desmoglein 3, with suprabasal acantholysis.

Why is "Dermatitis herpetiformis" not the answer?

Dermatitis herpetiformis is intensely itchy with grouped vesicles.

Why is "Bullous pemphigoid" not the answer?

Bullous pemphigoid has tense, stable bullae.

Why is "Lichen planus" not the answer?

Lichen planus is a papular eruption.

What concept does this question test?

It tests Blistering disorders in Dermatology. Bullous pemphigoid has tense blisters, subepidermal splits and a negative Nikolsky sign.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Blistering disorders?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.