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Dermatology · Blistering disorders
Sample itemWhy is pemphigus vulgaris clinically serious?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Flaccid bullae and mucosal erosions can cause major skin loss
Pemphigus vulgaris causes intraepidermal acantholysis with fragile bullae and painful mucosal erosions, risking fluid loss and infection.
Option by option
A. It only affects hair follicles
Hair follicle disease does not define pemphigus.
B. Flaccid bullae and mucosal erosions can cause major skin loss (correct)
Correct: fragile widespread erosions create systemic risk.
C. It is confined to one toe
Pemphigus is not typically confined to one toe.
D. It produces harmless stable freckles
Freckles are unrelated pigment lesions.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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