Pigmentary disorders: tranexamic acid in melasma: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Dermatology · Pigmentary disorders: tranexamic acid in melasma

Sample item

Which patient should NOT receive oral tranexamic acid for refractory melasma?

AA woman with a history of deep vein thrombosisBA woman using sunscreenCA woman with mild acneDA woman with seasonal allergic rhinitis

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. A woman with a history of deep vein thrombosis

Oral tranexamic acid is an antifibrinolytic that can reduce melasma, but it is contraindicated in patients with a history of venous or arterial thromboembolism or high thrombotic risk. Oestrogen use adds to the risk. It is used in short courses with photoprotection.

Option by option

A. A woman with a history of deep vein thrombosis (correct)
Correct. Prior deep vein thrombosis is a contraindication.
B. A woman using sunscreen
Sunscreen use is encouraged.
C. A woman with mild acne
Acne does not contraindicate it.
D. A woman with seasonal allergic rhinitis
Allergic rhinitis does not contraindicate it.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is A, A woman with a history of deep vein thrombosis. Oral tranexamic acid is an antifibrinolytic that can reduce melasma, but it is contraindicated in patients with a history of venous or arterial thromboembolism or high thrombotic risk.

Why is "A woman using sunscreen" not the answer?

Sunscreen use is encouraged.

Why is "A woman with mild acne" not the answer?

Acne does not contraindicate it.

Why is "A woman with seasonal allergic rhinitis" not the answer?

Allergic rhinitis does not contraindicate it.

What concept does this question test?

It tests Pigmentary disorders: tranexamic acid in melasma in Dermatology. Oestrogen use adds to the risk. It is used in short courses with photoprotection.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Pigmentary disorders: tranexamic acid in melasma?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.