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Dermatology · Hair disorders: intralesional triamcinolone
Sample itemA 25-year-old has two patches of alopecia areata on the scalp. Which local therapy is commonly used, and what is its main local adverse effect?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Intralesional triamcinolone, which can cause skin atrophy and hypopigmentation
Intralesional triamcinolone acetonide at low concentration is first-line for limited alopecia areata in adults, injected intradermally at intervals of 4 to 6 weeks. Local atrophy and hypopigmentation are the main adverse effects, which can be reduced by using the lowest effective concentration and avoiding excessive volume. It is less suited to extensive disease.
Option by option
A. Intralesional methotrexate, which causes alopecia
Intralesional methotrexate is not a standard therapy.
B. Oral antihistamines, which cause hirsutism
Antihistamines do not regrow hair.
C. Topical mupirocin, which causes folliculitis
Mupirocin does not treat alopecia areata.
D. Intralesional triamcinolone, which can cause skin atrophy and hypopigmentation (correct)
Correct. Intralesional triamcinolone can cause atrophy and hypopigmentation.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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