Benign gynaecology: overactive bladder therapy: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Benign gynaecology: overactive bladder therapy

Sample item

A 60-year-old woman with overactive bladder and well-controlled hypertension and dry mouth on oxybutynin needs an alternative. Which drug acts by relaxing the detrusor through beta-3 adrenergic stimulation?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Mirabegron

Mirabegron is a beta-3 adrenoceptor agonist that relaxes the detrusor during storage and avoids anticholinergic side effects such as dry mouth, constipation and cognitive effects. It can raise blood pressure, so monitoring is needed in hypertensive patients. The other options are antimuscarinic or tricyclic agents with anticholinergic effects.

Option by option

  • A. Solifenacin

    Solifenacin is an antimuscarinic.

  • B. Imipramine

    Imipramine has anticholinergic and adrenergic effects and is not a beta-3 agonist.

  • C. Mirabegron (correct)

    Correct. Mirabegron is a beta-3 agonist.

  • D. Tolterodine

    Tolterodine is an antimuscarinic.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is C, Mirabegron. Mirabegron is a beta-3 adrenoceptor agonist that relaxes the detrusor during storage and avoids anticholinergic side effects such as dry mouth, constipation and cognitive effects.

Why is "Solifenacin" not the answer?

Solifenacin is an antimuscarinic.

Why is "Imipramine" not the answer?

Imipramine has anticholinergic and adrenergic effects and is not a beta-3 agonist.

Why is "Tolterodine" not the answer?

Tolterodine is an antimuscarinic.

What concept does this question test?

It tests Benign gynaecology: overactive bladder therapy in OBG. It can raise blood pressure, so monitoring is needed in hypertensive patients. The other options are antimuscarinic or tricyclic agents with anticholinergic effects.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Benign gynaecology: overactive bladder therapy?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.