Bone tumours: response to chemotherapy: practice question

A Orthopaedics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Orthopaedics · Bone tumours: response to chemotherapy

Sample item

After neoadjuvant chemotherapy for osteosarcoma, histology of the resected specimen shows more than 90 percent tumour necrosis. What does this signify?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. A good response, which is associated with better survival

Histological response to preoperative chemotherapy, such as the Huvos grading, is the strongest prognostic factor in osteosarcoma. Necrosis of 90 percent or more is a good response and predicts better survival. Poor responders may be offered a change of postoperative chemotherapy.

Option by option

  • A. Tumour progression

    Extensive necrosis indicates response, not progression.

  • B. A benign tumour

    The tumour is a malignant sarcoma, not a benign lesion.

  • C. A poor response needing amputation

    A poor response is below 90 percent necrosis.

  • D. A good response, which is associated with better survival (correct)

    Correct. Over 90 percent necrosis is a good response linked with better survival.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Orthopaedics question

What is the answer to this Orthopaedics question?

The best answer is D, A good response, which is associated with better survival. Histological response to preoperative chemotherapy, such as the Huvos grading, is the strongest prognostic factor in osteosarcoma.

Why is "Tumour progression" not the answer?

Extensive necrosis indicates response, not progression.

Why is "A benign tumour" not the answer?

The tumour is a malignant sarcoma, not a benign lesion.

Why is "A poor response needing amputation" not the answer?

A poor response is below 90 percent necrosis.

What concept does this question test?

It tests Bone tumours: response to chemotherapy in Orthopaedics. Necrosis of 90 percent or more is a good response and predicts better survival. Poor responders may be offered a change of postoperative chemotherapy.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Bone tumours: response to chemotherapy?

Pair each fracture with its classic complication and nerve injured. Then use the flashcards and the other Orthopaedics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.