Papulosquamous: long-term PUVA adverse effect: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Papulosquamous: long-term PUVA adverse effect

Sample item

A man with severe psoriasis has had more than 200 PUVA sessions over many years. Which malignancy is he at particular risk of developing?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Squamous cell carcinoma of the skin

Cumulative PUVA exposure increases the risk of cutaneous squamous cell carcinoma, especially of the genitals and exposed sites, and also of melanoma. Patients need lifelong skin surveillance and genital shielding in men. Narrowband UVB carries a lower risk.

Option by option

  • A. Non-Hodgkin lymphoma of the gut

    Gut lymphoma has no link with PUVA.

  • B. Hepatocellular carcinoma

    Hepatocellular carcinoma is not a PUVA effect.

  • C. Basal cell carcinoma only

    SCC, not BCC alone, is the dominant PUVA malignancy.

  • D. Squamous cell carcinoma of the skin (correct)

    Correct. PUVA carries a dose-related squamous cell carcinoma risk.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is D, Squamous cell carcinoma of the skin. Cumulative PUVA exposure increases the risk of cutaneous squamous cell carcinoma, especially of the genitals and exposed sites, and also of melanoma.

Why is "Non-Hodgkin lymphoma of the gut" not the answer?

Gut lymphoma has no link with PUVA.

Why is "Hepatocellular carcinoma" not the answer?

Hepatocellular carcinoma is not a PUVA effect.

Why is "Basal cell carcinoma only" not the answer?

SCC, not BCC alone, is the dominant PUVA malignancy.

What concept does this question test?

It tests Papulosquamous: long-term PUVA adverse effect in Dermatology. Patients need lifelong skin surveillance and genital shielding in men. Narrowband UVB carries a lower risk.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Papulosquamous: long-term PUVA adverse effect?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.