Nucleotide metabolism: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Nucleotide metabolism

Sample item

What enzyme joins Okazaki fragments during DNA replication?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. DNA ligase

The core Nucleotide metabolism principle identifies DNA ligase as the best answer because it most directly explains the biochemical pathway or tissue response described in the stem.

Option by option

  • A. Helicase

    Helicase does not account for the central finding in this sample.

  • B. Primase

    Primase is relevant in another context but is not the best answer here.

  • C. DNA ligase (correct)

    Correct. DNA ligase is supported by the key clue given.

  • D. DNA polymerase

    DNA polymerase does not match the stated nucleotide metabolism mechanism.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Biochemistry questions

Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is C, DNA ligase. The core Nucleotide metabolism principle identifies DNA ligase as the best answer because it most directly explains the biochemical pathway or tissue response described in the stem.

Why is "Helicase" not the answer?

Helicase does not account for the central finding in this sample.

Why is "Primase" not the answer?

Primase is relevant in another context but is not the best answer here.

Why is "DNA polymerase" not the answer?

DNA polymerase does not match the stated nucleotide metabolism mechanism.

What concept does this question test?

It tests Nucleotide metabolism in Biochemistry. The correct option holds because: Correct. DNA ligase is supported by the key clue given.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Nucleotide metabolism?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.