Amino acid metabolism: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Amino acid metabolism

Sample item

What is the major transport form of ammonia from muscle to liver?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Alanine

Muscle transfers amino nitrogen to pyruvate to form alanine, which carries nitrogen to liver for urea production in the glucose-alanine cycle.

Option by option

  • A. Lysine

    Lysine is essential and ketogenic, not the main ammonia shuttle.

  • B. Alanine (correct)

    Correct: alanine transports amino nitrogen from muscle to liver.

  • C. Leucine

    Leucine is a branched-chain amino acid used in muscle metabolism.

  • D. Phenylalanine

    Phenylalanine is converted to tyrosine under normal metabolism.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is B, Alanine. Muscle transfers amino nitrogen to pyruvate to form alanine, which carries nitrogen to liver for urea production in the glucose-alanine cycle.

Why is "Lysine" not the answer?

Lysine is essential and ketogenic, not the main ammonia shuttle.

Why is "Leucine" not the answer?

Leucine is a branched-chain amino acid used in muscle metabolism.

Why is "Phenylalanine" not the answer?

Phenylalanine is converted to tyrosine under normal metabolism.

What concept does this question test?

It tests Amino acid metabolism in Biochemistry. The correct option holds because: Correct: alanine transports amino nitrogen from muscle to liver.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Amino acid metabolism?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.