Oxidative phosphorylation: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Oxidative phosphorylation

Sample item

What molecule directly drives ATP synthase in mitochondria?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Proton gradient

Electron transport pumps protons across the inner mitochondrial membrane, and their return down this electrochemical gradient drives ATP synthase.

Option by option

  • A. Proton gradient (correct)

    Correct: proton motive force powers mitochondrial ATP synthase.

  • B. Glucose

    Glucose is metabolized upstream and does not directly turn ATP synthase.

  • C. Carbon dioxide

    Carbon dioxide is a metabolic waste product, not the energy gradient.

  • D. Sodium gradient

    Sodium gradient is not the main mitochondrial ATP synthase driver.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is A, Proton gradient. Electron transport pumps protons across the inner mitochondrial membrane, and their return down this electrochemical gradient drives ATP synthase.

Why is "Glucose" not the answer?

Glucose is metabolized upstream and does not directly turn ATP synthase.

Why is "Carbon dioxide" not the answer?

Carbon dioxide is a metabolic waste product, not the energy gradient.

Why is "Sodium gradient" not the answer?

Sodium gradient is not the main mitochondrial ATP synthase driver.

What concept does this question test?

It tests Oxidative phosphorylation in Biochemistry. The correct option holds because: Correct: proton motive force powers mitochondrial ATP synthase.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Oxidative phosphorylation?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.