Analgesics: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Analgesics

Sample item

What organ is most threatened by acetaminophen overdose?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Liver

Acetaminophen overdose depletes glutathione and allows toxic metabolite accumulation, causing potentially severe hepatic necrosis without timely treatment.

Option by option

  • A. Cornea

    Cornea is not the principal acetaminophen target organ.

  • B. Liver (correct)

    Correct: overdose can cause life-threatening hepatic injury.

  • C. Thyroid

    Thyroid injury is not the typical overdose consequence.

  • D. Middle ear

    Middle ear is not affected in this toxicity pattern.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Liver. Acetaminophen overdose depletes glutathione and allows toxic metabolite accumulation, causing potentially severe hepatic necrosis without timely treatment.

Why is "Cornea" not the answer?

Cornea is not the principal acetaminophen target organ.

Why is "Thyroid" not the answer?

Thyroid injury is not the typical overdose consequence.

Why is "Middle ear" not the answer?

Middle ear is not affected in this toxicity pattern.

What concept does this question test?

It tests Analgesics in Pharmacology. The correct option holds because: Correct: overdose can cause life-threatening hepatic injury.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Analgesics?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.