Clinical pharmacology: practice question

A General Medicine question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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General Medicine · Clinical pharmacology

Sample item

What is the key danger of prescribing an NSAID to a dehydrated patient with kidney impairment?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Worsening renal perfusion and acute kidney injury

NSAIDs reduce prostaglandin-mediated afferent arteriolar dilation and can worsen renal perfusion, especially during dehydration or pre-existing kidney disease.

Option by option

  • A. Worsening renal perfusion and acute kidney injury (correct)

    Correct: prostaglandin blockade can reduce glomerular perfusion.

  • B. Correction of severe hypoglycaemia

    They do not correct low blood glucose.

  • C. Guaranteed prevention of ulcers

    They may increase rather than prevent ulcer risk.

  • D. Immediate cure of hypertension

    NSAIDs do not cure hypertension.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More General Medicine questions

Questions about this General Medicine question

What is the answer to this General Medicine question?

The best answer is A, Worsening renal perfusion and acute kidney injury. NSAIDs reduce prostaglandin-mediated afferent arteriolar dilation and can worsen renal perfusion, especially during dehydration or pre-existing kidney disease.

Why is "Correction of severe hypoglycaemia" not the answer?

They do not correct low blood glucose.

Why is "Guaranteed prevention of ulcers" not the answer?

They may increase rather than prevent ulcer risk.

Why is "Immediate cure of hypertension" not the answer?

NSAIDs do not cure hypertension.

What concept does this question test?

It tests Clinical pharmacology in General Medicine. The correct option holds because: Correct: prostaglandin blockade can reduce glomerular perfusion.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Clinical pharmacology?

For each disease know the classic presentation, the best test, and the first-line treatment. Then use the flashcards and the other General Medicine questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.