Immunopathology: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Immunopathology

Sample item

What mechanism causes type IV hypersensitivity?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. T-cell mediated delayed immune response

Type IV hypersensitivity is driven by sensitized T cells and macrophage activation, producing delayed inflammation such as contact dermatitis.

Option by option

  • A. IgE cross-linking on mast cells

    IgE-mediated reactions are type I.

  • B. Immune complexes only in blood

    Immune complexes define type III mechanisms.

  • C. T-cell mediated delayed immune response (correct)

    Correct: cellular immunity mediates delayed hypersensitivity.

  • D. Direct complement deficiency

    Complement deficiency is not the core type IV mechanism.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, T-cell mediated delayed immune response. Type IV hypersensitivity is driven by sensitized T cells and macrophage activation, producing delayed inflammation such as contact dermatitis.

Why is "IgE cross-linking on mast cells" not the answer?

IgE-mediated reactions are type I.

Why is "Immune complexes only in blood" not the answer?

Immune complexes define type III mechanisms.

Why is "Direct complement deficiency" not the answer?

Complement deficiency is not the core type IV mechanism.

What concept does this question test?

It tests Immunopathology in Pathology. The correct option holds because: Correct: cellular immunity mediates delayed hypersensitivity.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Immunopathology?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.