Immunopathology: Goodpasture syndrome: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Immunopathology: Goodpasture syndrome

Sample item

A patient has haemoptysis and rapidly progressive glomerulonephritis. Linear IgG staining along glomerular basement membranes indicates antibodies against what?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Type IV collagen

Goodpasture syndrome is caused by antibodies to the alpha-3 chain of type IV collagen in glomerular and alveolar basement membranes. Immunofluorescence is linear rather than granular.

Option by option

  • A. Desmoglein

    Desmoglein antibodies cause pemphigus vulgaris.

  • B. Double-stranded DNA

    Anti-dsDNA antibodies are associated with SLE and granular immune deposits.

  • C. Type IV collagen (correct)

    Correct. Anti-GBM antibodies target type IV collagen.

  • D. Acetylcholine receptor

    Acetylcholine-receptor antibodies cause myasthenia gravis.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Type IV collagen. Goodpasture syndrome is caused by antibodies to the alpha-3 chain of type IV collagen in glomerular and alveolar basement membranes.

Why is "Desmoglein" not the answer?

Desmoglein antibodies cause pemphigus vulgaris.

Why is "Double-stranded DNA" not the answer?

Anti-dsDNA antibodies are associated with SLE and granular immune deposits.

Why is "Acetylcholine receptor" not the answer?

Acetylcholine-receptor antibodies cause myasthenia gravis.

What concept does this question test?

It tests Immunopathology: Goodpasture syndrome in Pathology. Immunofluorescence is linear rather than granular.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Immunopathology: Goodpasture syndrome?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.