Haematology: chronic myeloid leukaemia: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Haematology: chronic myeloid leukaemia

Sample item

The BCR-ABL fusion in chronic myeloid leukaemia encodes a constitutively active what?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Tyrosine kinase

The t(9;22) Philadelphia chromosome creates BCR-ABL, an always-active tyrosine kinase that drives myeloid proliferation. Tyrosine-kinase inhibitors such as imatinib target this abnormal protein.

Option by option

  • A. Tumour-suppressor phosphatase

    BCR-ABL is oncogenic, not a tumour suppressor.

  • B. Tyrosine kinase (correct)

    Correct. BCR-ABL signalling is tyrosine-kinase dependent.

  • C. Serine protease

    A serine protease does not explain the Philadelphia chromosome effect.

  • D. DNA helicase

    Helicase defects are not the core lesion in CML.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is B, Tyrosine kinase. The t(9;22) Philadelphia chromosome creates BCR-ABL, an always-active tyrosine kinase that drives myeloid proliferation.

Why is "Tumour-suppressor phosphatase" not the answer?

BCR-ABL is oncogenic, not a tumour suppressor.

Why is "Serine protease" not the answer?

A serine protease does not explain the Philadelphia chromosome effect.

Why is "DNA helicase" not the answer?

Helicase defects are not the core lesion in CML.

What concept does this question test?

It tests Haematology: chronic myeloid leukaemia in Pathology. Tyrosine-kinase inhibitors such as imatinib target this abnormal protein.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Haematology: chronic myeloid leukaemia?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.