Immunopharmacology: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Immunopharmacology

Sample item

What is the principal risk of TNF-alpha inhibitor therapy?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Reactivation of latent tuberculosis

TNF-alpha is important for granuloma maintenance, so its inhibition can allow latent tuberculosis and other opportunistic infections to reactivate.

Option by option

  • A. Immediate bone mineralization

    Bone mineralization is unrelated.

  • B. Prevention of all infections

    Immunosuppression increases rather than prevents infection.

  • C. Reactivation of latent tuberculosis (correct)

    Correct: impaired granuloma containment can reactivate TB.

  • D. Reversal of viral hepatitis

    Viral hepatitis is not reversed by TNF blockade.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is C, Reactivation of latent tuberculosis. TNF-alpha is important for granuloma maintenance, so its inhibition can allow latent tuberculosis and other opportunistic infections to reactivate.

Why is "Immediate bone mineralization" not the answer?

Bone mineralization is unrelated.

Why is "Prevention of all infections" not the answer?

Immunosuppression increases rather than prevents infection.

Why is "Reversal of viral hepatitis" not the answer?

Viral hepatitis is not reversed by TNF blockade.

What concept does this question test?

It tests Immunopharmacology in Pharmacology. The correct option holds because: Correct: impaired granuloma containment can reactivate TB.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Immunopharmacology?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.