Drug interactions: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Drug interactions

Sample item

Why can macrolide antibiotics increase toxicity of some statins?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. They inhibit CYP-mediated statin metabolism

Some macrolides inhibit CYP3A4, increasing concentrations of susceptible statins and raising the risk of myopathy or rhabdomyolysis.

Option by option

  • A. They increase renal filtration dramatically

    Renal filtration is not dramatically increased.

  • B. They block intestinal glucose absorption

    Glucose absorption is unrelated.

  • C. They bind all statins in the gut

    Gut binding is not the principal interaction.

  • D. They inhibit CYP-mediated statin metabolism (correct)

    Correct: metabolic inhibition increases statin exposure.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, They inhibit CYP-mediated statin metabolism. Some macrolides inhibit CYP3A4, increasing concentrations of susceptible statins and raising the risk of myopathy or rhabdomyolysis.

Why is "They increase renal filtration dramatically" not the answer?

Renal filtration is not dramatically increased.

Why is "They block intestinal glucose absorption" not the answer?

Glucose absorption is unrelated.

Why is "They bind all statins in the gut" not the answer?

Gut binding is not the principal interaction.

What concept does this question test?

It tests Drug interactions in Pharmacology. The correct option holds because: Correct: metabolic inhibition increases statin exposure.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Drug interactions?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.