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Dermatology · Pigmented lesions: melanoma
Sample itemWhich change in a pigmented lesion is most concerning for melanoma?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Asymmetry with evolving color and border irregularity
Melanoma warning signs include asymmetry, irregular border, color variation, increasing diameter, and evolution. Any suspicious changing lesion needs appropriate urgent dermatologic assessment.
Option by option
A. Asymmetry with evolving color and border irregularity (correct)
Correct. Evolution with asymmetry and color or border change is concerning.
B. A blanching wheal lasting one hour
A transient blanching wheal is urticaria.
C. Stable symmetric uniform mole since childhood
A stable uniform lifelong nevus is less concerning, though assessment depends on the full lesion history.
D. Freckling after sun exposure
Freckles are common sun-related macules without the described malignant features.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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