Autoimmune blistering disease: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Autoimmune blistering disease

Sample item

A patient has painful oral erosions and flaccid bullae that rupture easily, with positive Nikolsky sign. Which diagnosis is most likely?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Pemphigus vulgaris

Pemphigus vulgaris is an intraepidermal autoimmune blistering disorder causing flaccid bullae, erosions, and frequent oral mucosal disease. It requires specialist diagnosis and immunosuppressive management.

Option by option

  • A. Urticaria

    Urticaria produces transient wheals, not erosions.

  • B. Pemphigus vulgaris (correct)

    Correct. Flaccid easily ruptured blisters with oral disease are characteristic.

  • C. Erythema multiforme minor

    Erythema multiforme has target lesions rather than persistent flaccid bullae.

  • D. Bullous pemphigoid

    Bullous pemphigoid causes tense subepidermal bullae and less mucosal involvement.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Dermatology questions

Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is B, Pemphigus vulgaris. Pemphigus vulgaris is an intraepidermal autoimmune blistering disorder causing flaccid bullae, erosions, and frequent oral mucosal disease.

Why is "Urticaria" not the answer?

Urticaria produces transient wheals, not erosions.

Why is "Erythema multiforme minor" not the answer?

Erythema multiforme has target lesions rather than persistent flaccid bullae.

Why is "Bullous pemphigoid" not the answer?

Bullous pemphigoid causes tense subepidermal bullae and less mucosal involvement.

What concept does this question test?

It tests Autoimmune blistering disease in Dermatology. It requires specialist diagnosis and immunosuppressive management.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Autoimmune blistering disease?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.