Laboratory biochemistry: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Laboratory biochemistry

Sample item

What does an isolated high unconjugated bilirubin suggest in haemolysis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Excess heme breakdown exceeding conjugation

Haemolysis increases heme breakdown and unconjugated bilirubin production; the liver may be unable to conjugate the increased load fully.

Option by option

  • A. Reduced albumin synthesis only

    Albumin does not determine bilirubin fraction alone.

  • B. Pancreatic enzyme deficiency

    Pancreatic enzymes are unrelated.

  • C. Complete biliary obstruction

    Obstruction raises conjugated bilirubin.

  • D. Excess heme breakdown exceeding conjugation (correct)

    Correct: excess bilirubin production raises indirect fraction.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is D, Excess heme breakdown exceeding conjugation. Haemolysis increases heme breakdown and unconjugated bilirubin production; the liver may be unable to conjugate the increased load fully.

Why is "Reduced albumin synthesis only" not the answer?

Albumin does not determine bilirubin fraction alone.

Why is "Pancreatic enzyme deficiency" not the answer?

Pancreatic enzymes are unrelated.

Why is "Complete biliary obstruction" not the answer?

Obstruction raises conjugated bilirubin.

What concept does this question test?

It tests Laboratory biochemistry in Biochemistry. The correct option holds because: Correct: excess bilirubin production raises indirect fraction.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Laboratory biochemistry?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.