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Pathology · Haemodynamics
Sample itemWhat mechanism causes oedema in nephrotic syndrome?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Reduced plasma oncotic pressure from albumin loss
Heavy urinary protein loss lowers serum albumin and plasma oncotic pressure, allowing fluid to leave vessels and accumulate in tissues.
Option by option
A. Reduced plasma oncotic pressure from albumin loss (correct)
Correct: low albumin reduces intravascular oncotic pull.
B. Excess red-cell production
Erythrocytosis is unrelated.
C. Vasoconstriction of afferent arterioles
Afferent vasoconstriction is not the primary mechanism.
D. Increased arterial oxygen content
Oxygen content does not cause nephrotic oedema.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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