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Pathology · Pulmonary pathology
Sample itemWhat is the fundamental abnormality in pulmonary fibrosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Excess interstitial collagen reducing lung compliance
Pulmonary fibrosis increases interstitial collagen, making lungs stiff, reducing compliance, and impairing diffusion across the alveolar-capillary membrane.
Option by option
A. Excess interstitial collagen reducing lung compliance (correct)
Correct: interstitial scarring produces restrictive physiology.
B. Pleural air under pressure
Pleural pressure air is tension pneumothorax.
C. Alveolar air trapping from bronchial collapse
Air trapping is obstructive disease.
D. Mucus plug in a single bronchus
Mucus plugs are localized airway obstruction.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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