Antenatal medicine: Rh alloimmunization: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Antenatal medicine: Rh alloimmunization

Sample item

An RhD-negative pregnant patient has anti-D antibodies detected at a clinically significant level. What is the main fetal risk?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Hemolytic disease of the fetus and newborn

Maternal anti-D antibodies can cross the placenta and hemolyze RhD-positive fetal red cells, causing anemia, hydrops, or neonatal jaundice. Sensitized pregnancies require specialist fetal-medicine surveillance.

Option by option

  • A. Pyloric stenosis

    Pyloric stenosis is an infant gastric-outlet disorder.

  • B. Hemolytic disease of the fetus and newborn (correct)

    Correct. Maternal alloantibodies can cause fetal and neonatal hemolysis.

  • C. Congenital hypothyroidism

    Congenital hypothyroidism has a different pathogenesis.

  • D. Neural tube defect

    Neural tube defects are unrelated to red-cell alloimmunization.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is B, Hemolytic disease of the fetus and newborn. Maternal anti-D antibodies can cross the placenta and hemolyze RhD-positive fetal red cells, causing anemia, hydrops, or neonatal jaundice.

Why is "Pyloric stenosis" not the answer?

Pyloric stenosis is an infant gastric-outlet disorder.

Why is "Congenital hypothyroidism" not the answer?

Congenital hypothyroidism has a different pathogenesis.

Why is "Neural tube defect" not the answer?

Neural tube defects are unrelated to red-cell alloimmunization.

What concept does this question test?

It tests Antenatal medicine: Rh alloimmunization in OBG. Sensitized pregnancies require specialist fetal-medicine surveillance.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antenatal medicine: Rh alloimmunization?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.