Acute inflammation: leukocyte migration: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Acute inflammation: leukocyte migration

Sample item

Which adhesion molecule mediates firm neutrophil attachment to endothelium during acute inflammation?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Integrin binding to ICAM-1

Leukocyte recruitment involves selectin-mediated rolling followed by integrin activation and firm adhesion to ICAM-1 or VCAM-1. Chemokines guide subsequent transmigration.

Option by option

  • A. Selectin-mediated rolling only

    Selectins mediate rolling rather than firm attachment.

  • B. Complement C3 cleavage only

    Complement has important chemotactic and opsonizing roles but is not the adhesion pair.

  • C. Integrin binding to ICAM-1 (correct)

    Correct. Integrin-ICAM interaction provides firm adhesion.

  • D. Histamine binding to H1 receptor

    Histamine increases permeability and vasodilation.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Integrin binding to ICAM-1. Leukocyte recruitment involves selectin-mediated rolling followed by integrin activation and firm adhesion to ICAM-1 or VCAM-1.

Why is "Selectin-mediated rolling only" not the answer?

Selectins mediate rolling rather than firm attachment.

Why is "Complement C3 cleavage only" not the answer?

Complement has important chemotactic and opsonizing roles but is not the adhesion pair.

Why is "Histamine binding to H1 receptor" not the answer?

Histamine increases permeability and vasodilation.

What concept does this question test?

It tests Acute inflammation: leukocyte migration in Pathology. Chemokines guide subsequent transmigration.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Acute inflammation: leukocyte migration?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.