Carcinogenesis: tumor suppressor genes: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Carcinogenesis: tumor suppressor genes

Sample item

What is the normal role of the RB protein in cell-cycle control?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Restrain G1-to-S progression by binding E2F

RB protein regulates the G1-S checkpoint by binding E2F transcription factors. Phosphorylation inactivates RB, permitting S-phase gene expression; RB loss removes this brake.

Option by option

  • A. Degrade collagen

    Collagen degradation is mediated by matrix metalloproteinases.

  • B. Synthesize DNA primers

    Primase synthesizes RNA primers for DNA replication.

  • C. Restrain G1-to-S progression by binding E2F (correct)

    Correct. RB normally prevents inappropriate entry into S phase.

  • D. Activate telomerase

    Telomerase is a separate enzyme involved in telomere maintenance.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Restrain G1-to-S progression by binding E2F. RB protein regulates the G1-S checkpoint by binding E2F transcription factors.

Why is "Degrade collagen" not the answer?

Collagen degradation is mediated by matrix metalloproteinases.

Why is "Synthesize DNA primers" not the answer?

Primase synthesizes RNA primers for DNA replication.

Why is "Activate telomerase" not the answer?

Telomerase is a separate enzyme involved in telomere maintenance.

What concept does this question test?

It tests Carcinogenesis: tumor suppressor genes in Pathology. Phosphorylation inactivates RB, permitting S-phase gene expression; RB loss removes this brake.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Carcinogenesis: tumor suppressor genes?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.