Infectious pathology: tuberculosis: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Infectious pathology: tuberculosis

Sample item

Which histologic pattern is most typical of tuberculosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Caseating granulomas with epithelioid histiocytes and giant cells

Tuberculosis classically causes granulomatous inflammation with central caseous necrosis, epithelioid macrophages, and multinucleated giant cells. Acid-fast stains and cultures help confirm infection.

Option by option

  • A. Diffuse eosinophilic infiltrate only

    Eosinophils dominate allergy and many parasitic infections.

  • B. Caseating granulomas with epithelioid histiocytes and giant cells (correct)

    Correct. Caseating granulomas are the classic tissue reaction.

  • C. Amyloid deposition

    Amyloid is a protein-deposition disorder.

  • D. Neutrophilic microabscesses only

    Neutrophilic abscesses are more typical of pyogenic bacteria.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is B, Caseating granulomas with epithelioid histiocytes and giant cells. Tuberculosis classically causes granulomatous inflammation with central caseous necrosis, epithelioid macrophages, and multinucleated giant cells.

Why is "Diffuse eosinophilic infiltrate only" not the answer?

Eosinophils dominate allergy and many parasitic infections.

Why is "Amyloid deposition" not the answer?

Amyloid is a protein-deposition disorder.

Why is "Neutrophilic microabscesses only" not the answer?

Neutrophilic abscesses are more typical of pyogenic bacteria.

What concept does this question test?

It tests Infectious pathology: tuberculosis in Pathology. Acid-fast stains and cultures help confirm infection.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Infectious pathology: tuberculosis?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.