Immunosuppressants: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Immunosuppressants

Sample item

What is the mechanism of methotrexate in inflammatory disease?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Inhibits dihydrofolate reductase and folate pathways

Methotrexate inhibits folate-dependent metabolism and has anti-inflammatory effects at low doses, requiring monitoring for marrow and liver toxicity.

Option by option

  • A. Activates IL-2 receptors

    IL-2 activation would stimulate immunity.

  • B. Inhibits dihydrofolate reductase and folate pathways (correct)

    Correct: folate-pathway inhibition underlies its effects.

  • C. Blocks acetylcholine release

    Acetylcholine release is unrelated.

  • D. Increases uric acid synthesis

    It does not raise urate synthesis.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Inhibits dihydrofolate reductase and folate pathways. Methotrexate inhibits folate-dependent metabolism and has anti-inflammatory effects at low doses, requiring monitoring for marrow and liver toxicity.

Why is "Activates IL-2 receptors" not the answer?

IL-2 activation would stimulate immunity.

Why is "Blocks acetylcholine release" not the answer?

Acetylcholine release is unrelated.

Why is "Increases uric acid synthesis" not the answer?

It does not raise urate synthesis.

What concept does this question test?

It tests Immunosuppressants in Pharmacology. The correct option holds because: Correct: folate-pathway inhibition underlies its effects.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Immunosuppressants?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.