Analgesics: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Analgesics

Sample item

Why is tramadol use with SSRIs monitored carefully?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Risk of serotonin toxicity and seizures

Tramadol has serotonergic activity and lowers seizure threshold, so combination with SSRIs can increase serotonin syndrome and seizure risk.

Option by option

  • A. It causes direct renal failure always

    Renal failure is not inevitable.

  • B. It prevents all opioid effects

    It has opioid activity itself.

  • C. It blocks SSRI absorption completely

    It does not fully block absorption.

  • D. Risk of serotonin toxicity and seizures (correct)

    Correct: overlapping serotonergic effect is hazardous.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, Risk of serotonin toxicity and seizures. Tramadol has serotonergic activity and lowers seizure threshold, so combination with SSRIs can increase serotonin syndrome and seizure risk.

Why is "It causes direct renal failure always" not the answer?

Renal failure is not inevitable.

Why is "It prevents all opioid effects" not the answer?

It has opioid activity itself.

Why is "It blocks SSRI absorption completely" not the answer?

It does not fully block absorption.

What concept does this question test?

It tests Analgesics in Pharmacology. The correct option holds because: Correct: overlapping serotonergic effect is hazardous.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Analgesics?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.